Referencing David Spade's situation, Artie asked Howard what he would do if the same thing happened to him, so Howard speculated that Beth would leave him. Howard added that, as a man, he still had the desire for "strange" (meaning new/different women), but he suppresses it because he wants to stay with Beth. Howard also recounted a time in Vegas when a chick pursued him so aggressively, he had to get up and leave.
Beth called in to say she would never forgive Howard if he cheated on her, as she's had a past relationship ruined by infidelity, and she still hasn't forgiven that guy. Beth continued, saying she meets interesting men all the time, but her commitment to (and love for) Howard keeps her from pursuing them. Beth then claimed she felt safe because everything Howard tells her is truthful, so Howard jokingly countered that "everything" was more like "90%."