Howard gave a caller named Brian the chance to play the Little Lupe Game, explaining that Spanish porn star Lupe Fuentes had been asked a series of questions--Brian must predict whether or not Lupe can answer them correctly.
If Brian gets 3 out of 5 right, he'll take home a cash prize.
The questions, followed by Brian's prediction and Lupe's answer:
How many states are in the US? Yes. "15." What do tadpoles grow up to be? No. "Butterflies?" Where is the Nile river? No. "New York?" Who is Vice President of the United States? No. "This guy that is, like, white hair."