David Arquette’s Touching Words for ‘Brother/Sister’ Alexis, Dead at 47

“Thank you all for your kind words of love and support,” the Stern Show regular wrote on Instagram

Arquette family (L-R) David, Rosanna, Alexis, Richmond, and PatriciaArquette family (L-R) David, Rosanna, Alexis, Richmond, and PatriciaPhoto: PRPhotos

Friend of the Stern Show David Arquette has lost his sibling Alexis Arquette who died on Sunday at the age of 47. Alexis was known as a transgender actress who appeared in the films "Pulp Fiction," "Bride of Chucky," and "Of Mice and Men."

"Our sister, Alexis Arquette, passed away this morning," brother Richmond Arquette said in a statement posted on Facebook that was also signed by Alexis' other siblings, Patricia Arquette, Rosanna Arquette, and David. "Alexis was a brilliant artist and painter, a singer, an entertainer and an actor."

David also honored Alexis with the following Instagram post:

Several stars in Hollywood shared their condolences on social media, including Roseanne Barr and Boy George. Fans will remember Alexis' role in "The Wedding Singer," where she played a Boy George impersonator.

Howard and Robin discussed the news of Alexis' passing on Monday morning's Stern Show. In 2001, Alexis had a cameo appearance on "Son of the Beach," the TV series executive produced by Howard.

"Sorry to hear that. Sorry for David," Howard said on-air of Alexis' death.

David thanked all who sent their well wishes with a message on Twitter:

Click here to read the Arquette family's full statement about Alexis. The Stern Show sends the entire Arquette family our condolences.